
JOYMODE is course-correction for supplements. Bringing science-backed research and honesty to categories that are famous for their lack of both. Our aim is to help men perform better across their core functions: Sex, Sleep, Cognition, Vitality, and Emotional Wellbeing.

Our Values
Make the most effective products in market
Formulate with clinically proven ingredients at their clinically supported dose
Help our customers make educated decisions about their health
Be honest about what our product can - and can’t - do for you
Our product philosophy
All ingredients have been assessed in peer reviewed journals
All ingredients have been studied and researched in humans
Multiple studies exist on all of our ingredients
At least one of the studies that supports an ingredient has a placebo group
These studies are usually single-blind & are often double-blind

Our Formulation Advisors

Bill Lagakos
Ph.D., Nutritional Biochemistry and Physiology at UC San Diego
Bill is a world-class scientist with postdoctoral training in Endocrinology, Metabolism and Circadian Biology.

Eric Trexler
Ph.D., Human Movement Science at UNC Chapel Hill
Eric is a sports nutrition expert who has published numerous scientific studies on dietary supplements, blood flow, body composition, and performance.
The Science Behind Our Formulas
Transparency and science drive everything we do. Here is some of the key research we used to formulate our products.
- Nitrate Ingestion: A review of the health and physical performance effectsWilliam T Clements, Sang-Rok Lee, and Richard J Bloomer Link
- Potential benefits of dietary nitrate ingestion in healthy and clinical populations: A brief reviewSinead T J McDonagh, Lee J Wylie, Christopher Thompson, Anni Vanhatalo, Andrew M Jones Link
L-Citrulline
- Oral L-citrulline supplementation improves erection hardness in men with mild erectile dysfunction. Luigi Cormio, Mario De Siati, Fabrizio Lorusso, Oscar Selvaggio, Lucia Mirabella, Francesca Sanguedolce, Giuseppe Carrieri. Link
- Oral L-citrulline supplementation improves erectile function in rats with acute arteriogenic erectile dysfunction. Arufumi Shiota, Yuji Hotta, Tomoya Kataoka, Masahiko Morita, Yasuhiro Maeda, Kazunori Kimura. Link
- Oral supplementation with a combination of L-citrulline and L-arginine rapidly increases plasma L-arginine concentration and enhances NO bioavailability. Masahiko Morita, Toshio Hayashi, Masayuki Ochiai, Morihiko Maeda, Tomoe Yamaguchi, Koichiro Ina Masafumi Kuzuya. Link
- L. Citrulline: a new player in the control of nitrogen homeostasis. Christophe Moinard, Luc Cynober. Link
- Treatment of erectile dysfunction with pycnogenol and L-arginine. R Stanislavov, V Nikolova. Link
- Oral L-citrulline and Transresveratrol Supplementation Improves Erectile Function in Men With Phosphodiesterase 5 Inhibitors: A Randomized, Double-Blind, Placebo-Controlled Crossover Pilot Study. Masato Shirai, Ippei Hiramatsu, Yusuke Aoki, Hirofumi Shimoyama, Taiki Mizuno , Taiji Nozaki, Shinichiro Fukuhara, Atsushi Iwasa, Shinji Kageyama, Akira Tsujimura. Link
Panax Ginseng
- Herbal dietary supplements for erectile dysfunction: A systematic review and meta-analysisFrancesca Borrelli, Cristiano Colalto, Domenico V Delfino, Marcello Iriti, and Angelo A Izzo Link
- Red ginseng for treating erectile dysfunction: a systematic reviewDai-Ja Jang, Myeong Soo Lee, Byung Cheul Shin, Young Cheoul Lee, and Edward Ernst Link
- What do most erectile dysfunction guidelines have in common? No evidence-based discussion or recommendation of heart-healthy lifestyle changes and/or Panax GinsengMark A Moyad and Kwangsung Park Link
Vitamin C
- Does vitamin C enhance nitric oxide bioavailability in a tetrahydrobiopterin-dependent manner? In vitro, in vivo and clinical studies. Alan Mortensen, Jens Lykkesfeldt. Link
- Vitamin C improves endothelium-dependent vasodilation by restoring nitric oxide activity in essential hypertension. S Taddei, A Virdis, L Ghiadoni, A Magagna, A Salvetti. Link
- Vitamin C improves endothelium-dependent vasodilation in patients with insulin-dependent diabetes mellitus. F K Timimi, H H Ting, E A Haley, M A Roddy, P Ganz, M A Creager. Link
- Clinical Evaluation of the Spermatogenic Activity of the Root Extract of Ashwagandha (Withania somnifera) in Oligospermic Males: A Pilot Study. Vijay R Ambiye, Deepak Langade, Swati Dongre, Pradnya Aptikar, Madhura Kulkarni, Atul Dongre. Link
- Withania somnifera improves semen quality by regulating reproductive hormone levels and oxidative stress in seminal plasma of infertile males. Mohammad Kaleem Ahmad, Abbas Ali Mahdi, Kamla Kant Shukla, Najmul Islam, Singh Rajender, Dama Madhukar, Satya Narain Shankhwar, Sohail Ahmad. Link
- Efficacy of Withania somnifera on seminal plasma metabolites of infertile males: a proton NMR study at 800 MHz. Ashish Gupta, Abbas Ali Mahdi, Kamla Kant Shukla, Mohammad Kaleem Ahmad, Navneeta Bansal, Pushplata Sankhwar, Satya Narain Sankhwar. Link
DIM
- Ah receptor binding properties of indole carbinols and induction of hepatic estradiol hydroxylation. P H Jellinck, P G Forkert, D S Riddick, A B Okey, J J Michnovicz, H L Bradlow. Link
- Attenuation of Carcinogenesis and the Mechanism Underlying by the Influence of Indole-3-carbinol and Its Metabolite 3,3'-Diindolylmethane: A Therapeutic Marvel. V L Maruthanila, J Poornima, S Mirunalini. Link
- 3,3'-diindolylmethane modulates estrogen metabolism in patients with thyroid proliferative disease: a pilot study. Shilpi Rajoria, Robert Suriano, Perminder Singh Parmar, Yushan Lisa Wilson, Uchechukwu Megwalu,2 Augustine Moscatello, H. Leon Bradlow, Daniel W. Sepkovic, Jan Geliebter, Stimson P. Schantz, and Raj K. Tiwari. Link
- Chemopreventive properties of 3,3'-diindolylmethane in breast cancer: evidence from experimental and human studies. Cynthia A Thomson, Emily Ho, Meghan B Strom. Link
- 3,3-Diindolylmethane (DIM): a nutritional intervention and its impact on breast density in healthy BRCA carriers. Rinat Yerushalmi, Sharon Bargil, Yaara Ber, Rachel Ozlavo, Tuval Sivan, Yael Rapson, Adi Pomerantz, Daliah Tsoref, Eran Sharon, Opher Caspi, Ahuvah Grubsrein , David Margel. Link
Magnesium
- The Interplay between Magnesium and Testosterone in Modulating Physical Function in Men. Marcello Maggio, Francesca De Vita, Fulvio Lauretani, Antonio Nouvenne, Tiziana Meschi, Andrea Ticinesi, Ligia J. Dominguez, Mario Barbagallo, Elisabetta Dall'Aglio, and Gian Paolo Ceda. Link
- Magnesium and anabolic hormones in older men. M. Maggio, G. P. Ceda, F. Lauretani, C. Cattabiani, E. Avantaggiato, S. Morganti, F. Ablondi, S. Bandinelli, L. J. Dominguez, M. Barbagallo, G. Paolisso, R. D. Semba, and L. Ferrucc. Link
Boron
- Comparative effects of daily and weekly boron supplementation on plasma steroid hormones and proinflammatory cytokines. Mohammad Reza Naghii, Mahmoud Mofid, Ali Reza Asgari, Mehdi Hedayati, Maryam-Saddat Daneshpour. Link
- Nothing Boring About Boron. Lara Pizzorno. Link
Zinc
- Zinc status and serum testosterone levels of healthy adults. A S Prasad, C S Mantzoros, F W Beck, J W Hess, G J Brewer. Link
- Dietary zinc deficiency alters 5 alpha-reduction and aromatization of testosterone and androgen and estrogen receptors in rat liver. A S Om, K W Chung. Link
- Relationship between serum levels of testosterone, zinc and selenium in infertile males attending fertility clinic in Nnewi, south east Nigeria. A O Oluboyo, R U Adijeh, C C Onyenekwe, B O Oluboyo, T C Mbaeri, C N Odiegwu, G O Chukwuma, U F Onwuasoanya. Link
- Effect of fatiguing bicycle exercise on thyroid hormone and testosterone levels in sedentary males supplemented with oral zinc. Mehmet Kilic. Link
- Relationship between testosterone and erectile dysfunction. Jacob Rajfer Link
- Correlation between serum testosterone level and concentrations of copper and zinc in hair tissue. Chung Soo Chang, Jong Bo Choi, Hae Jin Kim, Sat Byul Park. Link
- In search of a safe natural sleep aidTheertham P Rao, Motoko Ozeki, and Lekh Juneja Link
- Effects of L-Theanine administration on stress-related symptoms and cognitive functions in healthy adults: A randomized controlled trialShinsuke Hidese, Shintaro Ogawa, Miho Ota, Ikki Ishida, Zenta Yasukawa, Makoto Ozeki, and Hiroshi Kunugi Link
Melatonin
- Melatonin treatment for age-related insomniaI V Zhdanova, R J Wurtman, M M Regan, J A Taylor, J P Shi, and O U Leclair Link
- Optimal melatonin dose in older adults: A clinical review of the literatureMackenzie Pierce, Sunny A Linnebur, Scott M Pearson, and Danielle R Fixen Link
Magnesium Glycinate
- Association of Magnesium intake with sleep duration and sleep quality: findings from the CARDIA studyYijia Zhang, Cheng Chen, Liping Lu, Kristen L Knutson, Mercedes R Carnethon, Alyce D Fly, Juhua Luo, David M Haas, James M Shikany, and Ka Kahe Link
- The effect of Magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trialBehnood Abbasi, Masud Kimiagar, Khosro Sadeghniiat, Minoo M Shirazi, Mehdi Hedayati, and Bahram Rashidkhani Link
- Enhancement of learning and memory by elevating brain MagnesiumInna Slutski, Nashat Abumaria, Long-Jun Wu, Chao Huang, Ling Zhang, Bo Li, Xiang Zhao, Arvind Govindarajan, Ming-Gao Zhao, Min Zhuo, Susumu Tonegawa, and Guosong Liu Link
Tart Cherry Extract
- Nutritional interventions to improve sleep in team-sport athletes: A narrative reviewMadeleine Gratwicke, Kathleen H Miles, David B Pyne, Kate L Pumpa, and Brad Clark Link
- Pilot study of Tart Cherry juice for the treatment of insomnia and investigation of mechanismsJack N Losso, John W Finley, Namrata Karki, Ann G Liu, Weihong Pan, Alfredo Prudente, Russell Tipton, Ying Yu, and Frank L Greenway Link
Manufacturing Standards




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