Philosophy

JOYMODE is course-correction for supplements. Bringing science-backed research and honesty to categories that are famous for their lack of both. Our aim is to help men perform better across their core functions: Sex, Sleep, Cognition, Vitality, and Emotional Wellbeing.

Our Values

Quality Driven

Make the most effective products in market

Led By Science

Formulate with clinically proven ingredients at their clinically supported dose

Knowledge Is Power

Help our customers make educated decisions about their health

Ingredients With Integrity

Be honest about what our product can - and can’t - do for you

Our product philosophy

1

All ingredients have been assessed in peer reviewed journals

2

All ingredients have been studied and researched in humans

3

Multiple studies exist on all of our ingredients

4

At least one of the studies that supports an ingredient has a placebo group

5

These studies are usually single-blind & are often double-blind

Our Formulation Advisors

Our formulation team is deeply passionate about health and wellness optimization across sleep, diet, exercise and supplementation. Whether they are reading studies on vitamin supplementation or a new exercise modality, their core orientation is to seek the truth. This truth seeking disposition drives us toward best-in-class products by pushing us toward quality science. Unlike most supplement companies, we felt like it was important to show you who is behind our products.

Bill Lagakos

Ph.D., Nutritional Biochemistry and Physiology at UC San Diego

Bill is a world-class scientist with postdoctoral training in Endocrinology, Metabolism and Circadian Biology.

Eric Trexler

Ph.D., Human Movement Science at UNC Chapel Hill

Eric is a sports nutrition expert who has published numerous scientific studies on dietary supplements, blood flow, body composition, and performance.

The Science Behind Our Formulas

Transparency and science drive everything we do. Here is some of the key research we used to formulate our products.

Sexual Performance Booster

Nitrosigine

Acute effects of Nitrosigine® and citrulline malate on vasodilation in young adults. Jeffrey M. Rogers, Joshua Gills, and Michelle Gray. Link
A clinical evaluation to determine the safety, pharmacokinetics, and pharmacodynamics of an inositol-stabilized arginine silicate dietary supplement in healthy adult males. Douglas S Kalman, Samantha Feldman, Adam Samson, and Diane R Krieger. Link
A Pharmacokinetic Evaluation of the Duration of Effect of Inositol-Stabilized Arginine Silicate and Arginine Hydrochloride in Healthy Adult Males. James Komorowski, Sara Perez Ojalvo. Link

L-Citrulline

Oral L-citrulline supplementation improves erection hardness in men with mild erectile dysfunction. Luigi Cormio, Mario De Siati, Fabrizio Lorusso, Oscar Selvaggio, Lucia Mirabella, Francesca Sanguedolce, Giuseppe Carrieri. Link
Oral L-citrulline supplementation improves erectile function in rats with acute arteriogenic erectile dysfunction. Arufumi Shiota, Yuji Hotta, Tomoya Kataoka, Masahiko Morita, Yasuhiro Maeda, Kazunori Kimura. Link
Oral supplementation with a combination of L-citrulline and L-arginine rapidly increases plasma L-arginine concentration and enhances NO bioavailability. Masahiko Morita, Toshio Hayashi, Masayuki Ochiai, Morihiko Maeda, Tomoe Yamaguchi, Koichiro Ina Masafumi Kuzuya. Link
L. Citrulline: a new player in the control of nitrogen homeostasis. Christophe Moinard, Luc Cynober. Link
Treatment of erectile dysfunction with pycnogenol and L-arginine. R Stanislavov, V Nikolova. Link
Oral L-citrulline and Transresveratrol Supplementation Improves Erectile Function in Men With Phosphodiesterase 5 Inhibitors: A Randomized, Double-Blind, Placebo-Controlled Crossover Pilot Study. Masato Shirai, Ippei Hiramatsu, Yusuke Aoki, Hirofumi Shimoyama, Taiki Mizuno , Taiji Nozaki, Shinichiro Fukuhara, Atsushi Iwasa, Shinji Kageyama, Akira Tsujimura. Link

Yohimbine

Efficacy and safety of a novel combination of L-arginine glutamate and yohimbine hydrochloride: a new oral therapy for erectile dysfunction. Thierry Lebret, Jean-Marie Hervé, Philippe Gorny, Manuel Worcel, Henry Botto. Link
Sexual Performance Anxiety. Robert E Pyke. Link
Yohimbine for erectile dysfunction: a systematic review and meta-analysis of randomized clinical trials. E Ernst, M H Pittler. Link

Vitamin C

Does vitamin C enhance nitric oxide bioavailability in a tetrahydrobiopterin-dependent manner? In vitro, in vivo and clinical studies. Alan Mortensen, Jens Lykkesfeldt. Link
Vitamin C improves endothelium-dependent vasodilation by restoring nitric oxide activity in essential hypertension. S Taddei, A Virdis, L Ghiadoni, A Magagna, A Salvetti. Link
Vitamin C improves endothelium-dependent vasodilation in patients with insulin-dependent diabetes mellitus. F K Timimi, H H Ting, E A Haley, M A Roddy, P Ganz, M A Creager. Link

Testosterone Support Complex

KSM66 Ashwagandha

Clinical Evaluation of the Spermatogenic Activity of the Root Extract of Ashwagandha (Withania somnifera) in Oligospermic Males: A Pilot Study. Vijay R Ambiye, Deepak Langade, Swati Dongre, Pradnya Aptikar, Madhura Kulkarni, Atul Dongre. Link
Withania somnifera improves semen quality by regulating reproductive hormone levels and oxidative stress in seminal plasma of infertile males. Mohammad Kaleem Ahmad, Abbas Ali Mahdi, Kamla Kant Shukla, Najmul Islam, Singh Rajender, Dama Madhukar, Satya Narain Shankhwar, Sohail Ahmad. Link
Efficacy of Withania somnifera on seminal plasma metabolites of infertile males: a proton NMR study at 800 MHz. Ashish Gupta, Abbas Ali Mahdi, Kamla Kant Shukla, Mohammad Kaleem Ahmad, Navneeta Bansal, Pushplata Sankhwar, Satya Narain Sankhwar. Link

DIM

Ah receptor binding properties of indole carbinols and induction of hepatic estradiol hydroxylation. P H Jellinck, P G Forkert, D S Riddick, A B Okey, J J Michnovicz, H L Bradlow. Link
Attenuation of Carcinogenesis and the Mechanism Underlying by the Influence of Indole-3-carbinol and Its Metabolite 3,3'-Diindolylmethane: A Therapeutic Marvel. V L Maruthanila, J Poornima, S Mirunalini. Link
3,3'-diindolylmethane modulates estrogen metabolism in patients with thyroid proliferative disease: a pilot study. Shilpi Rajoria, Robert Suriano, Perminder Singh Parmar, Yushan Lisa Wilson, Uchechukwu Megwalu,2 Augustine Moscatello, H. Leon Bradlow, Daniel W. Sepkovic, Jan Geliebter, Stimson P. Schantz, and Raj K. Tiwari. Link
Chemopreventive properties of 3,3'-diindolylmethane in breast cancer: evidence from experimental and human studies. Cynthia A Thomson, Emily Ho, Meghan B Strom. Link
3,3-Diindolylmethane (DIM): a nutritional intervention and its impact on breast density in healthy BRCA carriers. Rinat Yerushalmi, Sharon Bargil, Yaara Ber, Rachel Ozlavo, Tuval Sivan, Yael Rapson, Adi Pomerantz, Daliah Tsoref, Eran Sharon, Opher Caspi, Ahuvah Grubsrein , David Margel. Link

Magnesium

The Interplay between Magnesium and Testosterone in Modulating Physical Function in Men. Marcello Maggio, Francesca De Vita, Fulvio Lauretani, Antonio Nouvenne, Tiziana Meschi, Andrea Ticinesi, Ligia J. Dominguez, Mario Barbagallo, Elisabetta Dall'Aglio, and Gian Paolo Ceda. Link
Magnesium and anabolic hormones in older men. M. Maggio, G. P. Ceda, F. Lauretani, C. Cattabiani, E. Avantaggiato, S. Morganti, F. Ablondi, S. Bandinelli, L. J. Dominguez, M. Barbagallo, G. Paolisso, R. D. Semba, and L. Ferrucc. Link

Boron

Comparative effects of daily and weekly boron supplementation on plasma steroid hormones and proinflammatory cytokines. Mohammad Reza Naghii, Mahmoud Mofid, Ali Reza Asgari, Mehdi Hedayati, Maryam-Saddat Daneshpour. Link
Nothing Boring About Boron. Lara Pizzorno. Link

Zinc

Zinc status and serum testosterone levels of healthy adults. A S Prasad, C S Mantzoros, F W Beck, J W Hess, G J Brewer. Link
Dietary zinc deficiency alters 5 alpha-reduction and aromatization of testosterone and androgen and estrogen receptors in rat liver. A S Om, K W Chung. Link
Relationship between serum levels of testosterone, zinc and selenium in infertile males attending fertility clinic in Nnewi, south east Nigeria. A O Oluboyo, R U Adijeh, C C Onyenekwe, B O Oluboyo, T C Mbaeri, C N Odiegwu, G O Chukwuma, U F Onwuasoanya. Link
Effect of fatiguing bicycle exercise on thyroid hormone and testosterone levels in sedentary males supplemented with oral zinc. Mehmet Kilic. Link
Relationship between testosterone and erectile dysfunction. Jacob Rajfer Link
Correlation between serum testosterone level and concentrations of copper and zinc in hair tissue. Chung Soo Chang, Jong Bo Choi, Hae Jin Kim, Sat Byul Park. Link